Epigenetic mechanisms of drug resistance in fungi
نویسندگان
چکیده
منابع مشابه
Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.
In a model system employing Chinese hamster V-79 cells, the DNA synthesis inhibitor 3'-azido-3'-deoxythymidine (BW A509U, AZT) was shown to induce genome-wide DNA hypermethylation, low-frequency silencing of thymidine kinase (TK; EC 2.7.1.21) gene expression, and resistance to AZT. Twenty-four hours of exposure of V-79 cells to 150 microM AZT led to > 2-fold enhancement of genomic 5-methylcytos...
متن کاملCopper resistance mechanisms in bacteria and fungi.
Copper is both an essential micronutrient and a toxic heavy metal for most living cells. The presence of high concentrations of cupric ions in the environment promotes the selection of microorganisms possessing genetic determinants for copper resistance. Several examples of chromosomal and plasmid copper-resistance systems in bacteria have been reported, and the mechanisms of resistance have st...
متن کاملAneuploidy and Drug Resistance in Pathogenic Fungi
Genomic imbalance resulting from aneuploidy is detrimental to the proliferation of cells in conditions suitable for normal growth and differentiation [1,2]. However, there is growing evidence that aneuploidy confers a significant growth advantage when cells undergo severe genetic or environmental perturbations [3–6]. For example, aneuploidy restored the ability to proliferate in yeast cells tha...
متن کاملDrug resistance in fungi – an emerging problem
Over the past quarter of a century, invasive fungal infections have emerged as an important cause of morbidity and mortality in immunocompromised patients. Although several new antifungal drugs have been licensed in recent years, antifungal drug resistance is becoming a major concern during treatment of such patients. The resistance may be intrinsic, acquired or clinical. The understanding of t...
متن کامل[Pleiotropic drug resistance ABC transporters in fungi].
Overexpression of pleiotropic drug resistance (PDR) efflux pumps of the ATP-binding cassette (ABC) transporter superfamily is the major cause of fungal multi-drug resistance and decreased efficacy of antifungal drugs. This review focused on recent progresses in understanding of the PDR efflux pumps of ABC transporter superfamily in Saccharomyces cerevisiae and the fungal pathogens Candida albic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Fungal Genetics and Biology
سال: 2019
ISSN: 1087-1845
DOI: 10.1016/j.fgb.2019.103253